Potent triazine-based dehydrocondensing reagents substituted by an amido group

• Munetaka Kunishima,
• Daiki Kato,
• Nobu Kimura,
• Masanori Kitamura,
• Kohei Yamada and
• Kazuhito Hioki

Beilstein J. Org. Chem. 2016, 12, 1897–1903, doi:10.3762/bjoc.12.179

• University, 1-1-3 Minatojima Chuo-ku, Kobe 655-8586, Japan 10.3762/bjoc.12.179 Abstract This study describes the synthesis of triazine-based dehydrocondensing reagents substituted by amido substituents and demonstrates their efficiency for dehydrocondensing reactions in MeOH and THF. N-Phenylbenzamido

• reactions; amido substituents; dehydrocondensing reactions; Fischer-type esterification; triazines; Introduction We previously reported that dehydrocondensing reactions between carboxylic acids 1 and amines 2 to give amides 3 efficiently proceed in water or alcohols in the presence of the dehydrocondensing

• DMT-MM. Conclusion We prepared triazine-based dehydrocondensing reagents bearing amido substituents and demonstrated their efficiency for their use in dehydrocondensing reactions in both MeOH and THF. The tertiary amide-type chlorotriazines III–VI gave better yields of the product 3a compared with the